The company, Hermatogenix chose Alderley Park in Cheshire above 10 other sites across the UK and Europe.
The molecular services firm aims to create up to 50 jobs for scientists in the region within three years.
Manchester Science Parks chief executive Rowena Burns predicts that this is a sign to come and represented true foreign investment in the regions life sciences sector.
Hematogenix is based in Tinley Park, Chicago, Illinois. Its laboratories focus on cancer related testing and other molecular based tests that serve a variety of physicians including pathologists, oncologists, urologists, gynecologists, and cardiologists, among others.
The company’s managing director, president and chief executive Dr Hytham Al-Masri said: “We are not bringing any people in from Chicago. In the first year we will create up to 15 jobs.
“In the next three years we could create up to 50 jobs depending on how it works out with certain trials.
“All those people will be employed from the fantastic talent pool that exists in Greater Manchester and the North West.”